State of fluidity as a biological base for processes in a living tissue. Fluidity of blood and mass and energy transfer through membranes in normal and pathological conditions. Elements of fluid mechanics, theory of both ordinary and fractional partial differential equations, pharmacokinetics, compartmental analysis, the Pontryagin maximum principle and programming in Mathematica. All the elements are related to fractional pharmacokinetics and toxicology. The analysis comprises just one drag or coadministration for different states of patients. 5P principles of contemporary medicine. System identification and simulations in time domain. Thus course is based on selected chapters of the below references.