Theoretical instruction Genome organization in Eukaryotes. Genetic information transmission at intra and intercellular level. Replication, transcription and translation. Regulation of gene expression. Cell division and gametogenesis. Mendel’s laws. Structure and function of human genome. Human Genome project. Genomics and transcriptomics. Monoallelic expression. Genomic imprinting. Mutations, pathogenesis and clinical manifestation of disease. Sex chromatin and dosage compensation. Functional genomics. Functional analyses of genes. DNA polymorphisms. Genotyping methods. Genetics and genomics of cancer. Practical laboratory The central dogma of molecular biology – transmission of genetic information from genes to protein – problem solving activities. DNA polymorphisms and usage of molecular markers in the analyses of hereditary diseases in human population. Use of online internet tools and databases on polymorphims in human popuation (dbSNP, dbVar), as well as its association with clinical manifestations (ClinVar). Exploration and analysis of human genome maps, localization of genes and polymorphisms of interest (MapViewer).