Diseases. The clinical picture of disease. The influence of drugs on organic systems. Cardiology, activity of the heart and blood vessels, volume depletion. Fundamentals of engineering diagnostics: x-ray, ultrasound, biopsy, imaging. Fundamentals of engineering therapy: orthopedic, osteosynthesis, artificial joints, prosthetic devices, vascular procedures, by-pass surgery, prosthetic valves, neurotherapy, catheterization, drainage areas of the body under pressure, radiation therapy of cancer, dialysis and plasmapheresis. Basic principles of making decisions in clinical medicine (examples from surgery, gynecology and obstetrics). Cardiovascular pathology with special emphasis on hemodynamics and therapeutic principles in cardiac surgery. Implants in cardiac surgery (mechanical, biological). Extracorporeal circulation. Types of pumps: pulsatile roller and centrifugal pumps, functioning, advantages and disadvantages, complications. Oxygenator construction. Assisted mechanical circulation. Robotic surgery. Endovascular surgery. Types and methods of application stents in large blood vessels. Balloon catheter technology. Biological and engineering rules in stent construction.