Courses – Fakultet tehničkih nauka u Novom Sadu

Subject: Bio-systems and information theory (17.BMIM2D)

Native organizations units: Department of Power, Electronic and Telecommunication Engineering

Type of studies	Title
Master Academic Studies	Biomedical Engineering (Year: 1, Semester: Winter)

General information:

Category	Theoretical-methodological
Scientific or art field	Telecommunications and Signal Processing
ECTS	6

Understanding the basic concepts of information theory (statistical coding, -compression , protective coding theory and sequence synchronization ) and their application in biological systems. The structure of DNA and RNA and understanding the encoding of information in living organisms and their modifications due to aging and pathology

Introduction to the basic principles of information theory and their applications in coding information related to protein synthesis in cells. Introduction to the process of translation and trascription. Using publiclz available databases and the use of available software. Microarray technique

Basic concepts of information theory, the concept of information, a measure of the amount of information, discrete sources with and without memory, statistical coding, protection coding, synchronization sequences, Markov models, Hidden Markov Models - Repetition: a basic biological concepts and nucleic acids DNA RNA gene, protein structure, and translation and transcription processes - Use available databases and annotations: structure and types: sequence databases, microarreys, protein interactions and structural base. - The alignment of DNA or protein sequences to determine the function of detected sequence , a quantitative measures of similarity. Alignment in pairs, patterns, profiles and multiple alignment - Analysis of gene expression: a microarrays technique - Methods of clustering and statistical analysis of the expression levels

Lectures,. Laboratory: access to qRT-PCR device for active DNA identification, including a joint analysis of sequences and gene expression tracking.

Authors	Title	Year	Publisher	Language
Gatlin, L.L.	Information Theory and the Living System	1972	Columbia University Press, New York	English
Bajić, D.	Search, synchronization, sequences, states: a different approach	2006	Fakultet tehničkih nauka, Novi Sad	English
Stroock, D.W.	An introduction to Markov processes	2005	Springer, Berlin	English
Isacs, N.	Markov chains theory and applications	1976	New York: John Wiley & Sons, New York	English
Marketa Zvelebil and Jeremy O. Baum	Understanding Bioinformatics	2008	Garland Sicence, Taylor and Francis group	English
P. Hanus, B. Goebel, J. Dingel, J. Weindl, J. Zech, Z. Dawy, J. Hagenauer, JC. Mueller	Information and communication theory in molecular biology	2007	Springer 90(2) 161-173	English
Parmigiani, G., et al.	The Analysis of Gene Expression Data	2003	Springer, New York	English